Women with an abnormal PALB2 gene have a 33% to 58% lifetime risk of developing breast cancer. Research on the PALB2 gene continues. While the risk for male breast, pancreatic, and ovarian cancers is thought to be increased, the exact degree of increase remains under investigation.
Whether you are a man or a woman, an abnormal BRCA1, BRCA2, or PALB2genetic test result means there is a 50% chance you could have passed that specific mutation on to your children.
While rare, it is possible for a person to have one BRCA1 and one BRCA2 mutation. Usually, this occurs in someone with Ashkenazi Jewish ancestry, due to the higher carrier frequency. For someone testing positive for both mutations, screening and risk reduction recommendations are the same as they would be for a person who tests positive for just one of these mutations. In a person who tests positive for both, the risk of passing each mutation to a child is 50%.
Researchers have been working to build their understanding of how breast cancers in women with BRCA mutations may differ from other breast cancers. Some of their findings include:
- Breast cancers in women withBRCA1 abnormalities are more likely to be estrogen-receptor-negative — meaning that the cancer’s growth is not fueled by the hormone estrogen — and to have high-grade cell growth. Both of these characteristics mean that chemotherapy will be more effective than hormonal (anti-estrogen) therapy in treating these cancers.
- BRCA1– andBRCA2-related cancers often test negative for overexpression of the gene known as HER2/neu. This genetic abnormality is not inherited, asBRCA1 and BRCA2 mutations are, but can develop in women over time. When the HER2 gene is overexpressed, the cancer cells have too many HER2 receptors (human epidermal growth factor receptor). HER2 receptors receive signals that stimulate the growth of breast cancer cells. HER2-positive breast cancer is considered to be a more aggressive form of the disease, but it can be treated with Herceptin (chemical name: trastuzumab), a medication that targets HER2 receptors. Most BRCA1- and BRCA2-related cancers cannot be treated with Herceptin because they are HER2-negative.
- Women withBRCA1 or BRCA2 gene abnormalities have no greater risk than other women of having multiple cancers in the same breast when their breast cancer is diagnosed.
- A 2005 study suggested that women with DCIS (ductal carcinoma in situ) are just as likely to have inherited gene abnormalities as those with invasive breast cancer.
If you have Breast Cancer
If you have a breast cancer gene abnormality and you develop breast cancer, your doctor will work with you to determine how your BRCA status might affect your treatment decisions. For example, if you have a BRCA1 mutation, the breast cancer is less likely to be estrogen-receptor-positive, which means that you may not be a candidate for treatment with hormonal therapy. If you have aBRCA2 mutation, however, you are more likely to be a candidate for hormonal therapy. Because research on the PALB2 gene is ongoing, it’s not clear yet if cancers caused by a PALB2 mutation are likely to have specific characteristics.
You’ll also want to talk with your doctor about reducing the risk of a new, second breast cancer or ovarian cancer. Women with breast cancer and a BRCA1 orBRCA2 abnormality have a significantly greater risk of developing a new, second breast cancer, as well as ovarian cancer.
If you want to lower your risk of a future Breast Cancer or Ovarian Cancer
Whether or not you’ve ever had breast cancer, knowing that you have a BRCAmutation means that you are at much greater risk of developing breast and possibly ovarian cancer in the future. The latest research offers these insights about strategies for lowering those risks:
- Preventive or “prophylactic” mastectomy, or removal of both breasts, has been found to reduce the risk of breast cancer in high-risk women by about 90%. After a diagnosis of one breast cancer in a woman with a genetic abnormality, the risk of her getting a new breast cancer is approximately 3% every year (for example, 15% over 5 years). Without aBRCA1 or BRCA2mutation, the risk of developing a new breast cancer after one episode of breast cancer is only 1% per year.
- Preventive or prophylactic salpingo-oophorectomy, or removal of both ovaries and fallopian tubes, can reduce breast cancer risk by as much as 50% when it is done before menopause, because it takes away the body’s main source of the hormone estrogen. It also can greatly reduce ovarian cancer risk. The timing of removing the ovaries differs depending on whether a person has aBRCA1 or BRCA2 For those with a BRCA1abnormality, the recommended timing of removing both ovaries and fallopian tubes is between ages 35 and 40. For those with a BRCA2 abnormality, removing ovaries and fallopian tubes can be considered between ages 40 and 45.
- Hormonal therapy medicines:Two SERMs (selective estrogen receptor modulators) and two aromatase inhibitors have been shown to reduce the risk of developing hormone-receptor-positive breast cancer in women at high risk.
- Tamoxifen has been shown to reduce the risk of first-time hormone-receptor-positive breast cancer in both postmenopausal and premenopausal women at high risk. Certain medicines may interfere with tamoxifen’s protective effects.
- Evista (chemical name: raloxifene) has been shown to reduce the risk of first-time hormone-receptor-positive breast cancer in postmenopausal women.
- Aromasin (chemical name: exemestane), an aromatase inhibitor, has been shown to reduce the risk of first-time hormone-receptor-positive breast cancer in postmenopausal women at high risk. Aromasin isn’t approved by the FDA for this use, but doctors may consider it a good alternative to tamoxifen or Evista. In 2013, the American Society of Clinical Oncology (ASCO) released new guidelines on using hormonal therapy medicines to reduce breast cancer risk in high-risk women. These guidelines recommend that doctors talk to high-risk postmenopausal women about using Aromasin to reduce risk. ASCO is a national organization of oncologists and other cancer care providers. ASCO guidelines give doctors recommendations for treatments that are supported by much credible research and experience.
- Arimidex (chemical name: anastrozole), also an aromatase inhibitor, has been shown to reduce the risk of first-time hormone-receptor-positive breast cancer in postmenopausal women at high risk. Like Aromasin, Arimidex isn’t approved by the FDA for this use, but doctors may consider it a good alternative to tamoxifen, Evista, or Aromasin.
Hormonal therapy medicines do not reduce the risk of hormone-receptor-negative breast cancer.
Researchers believe that hormonal therapy medicines will likely lower breast cancer risk in women with an abnormal PALB2 gene, but no specific studies have been done yet.
If you want to try to increase the odds of early detection
Another option besides preventive surgery is to undergo more frequent cancer screenings in an effort to catch cancer early, should it ever develop. Although more frequent screenings do not guarantee early detection of cancer, they are generally recommended for women who do not wish to have preventive surgery.
You can work with your doctor to come up with a screening schedule that is right for you. For example, you might take the following steps:
- Begin annual breast MRI at age 25 or mammogram if breast MRI is unavailable. Screening may start sooner if a family member has been diagnosed under the age of 30. Between ages 30 and 75, begin annual mammogram and breast MRI. For women over the age of 75, screening should be considered on an individual basis with their physicians. Men should receive yearly clinical breast exam starting at age 35, and they should start performing breast self-exam at age 35. Consider participating in a clinical trial evaluating newer methods of early detection.
- Begin annual screening with pelvic exam by a gynecologist by age 25. Between ages 30 and 35, consider ovarian cancer screening with annual pelvic ultrasound with an intravaginal probe and blood tests for a special protein called CA-125. Consider participating in a clinical trial evaluating newer methods of early detection.
- Have a clinical breast exam every 6 months, and examine your breasts monthly.
Consider participating in a clinical trial of cancer prevention strategies.
Know your Risk of Cancer by Testing your BRCA1, BRCA2, or PALB2 genes.
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